diff --git a/core/blockchain.go b/core/blockchain.go
index 93c40591c6..8ead80c253 100644
--- a/core/blockchain.go
+++ b/core/blockchain.go
@@ -2202,11 +2202,17 @@ func (bc *BlockChain) reorg(oldHead *types.Header, newHead *types.Block) error {
 
 	// Delete useless indexes right now which includes the non-canonical
 	// transaction indexes, canonical chain indexes which above the head.
-	indexesBatch := bc.db.NewBatch()
-	for _, tx := range types.HashDifference(deletedTxs, addedTxs) {
+	var (
+		indexesBatch = bc.db.NewBatch()
+		diffs        = types.HashDifference(deletedTxs, addedTxs)
+	)
+	for _, tx := range diffs {
 		rawdb.DeleteTxLookupEntry(indexesBatch, tx)
 	}
-
+	// Reset the tx lookup cache in case some indexes are removed.
+	if len(diffs) > 0 {
+		bc.txLookupCache.Purge()
+	}
 	// Delete all hash markers that are not part of the new canonical chain.
 	// Because the reorg function does not handle new chain head, all hash
 	// markers greater than or equal to new chain head should be deleted.