diff --git a/core/state_transition.go b/core/state_transition.go
index bd7e5daeff..6286256559 100644
--- a/core/state_transition.go
+++ b/core/state_transition.go
@@ -481,7 +481,7 @@ func (st *stateTransition) execute() (*ExecutionResult, error) {
 	// Check clause 6
 	value, overflow := uint256.FromBig(msg.Value)
 	if overflow {
-		return nil, fmt.Errorf("%w: address %v", ErrInsufficientFundsForTransfer, msg.From.Hex())
+		return nil, types.ErrUint256Overflow
 	}
 	if !value.IsZero() && !st.evm.Context.CanTransfer(st.state, msg.From, value) {
 		return nil, fmt.Errorf("%w: address %v", ErrInsufficientFundsForTransfer, msg.From.Hex())
diff --git a/core/txpool/validation.go b/core/txpool/validation.go
index 13b1bfa312..aa15ee869e 100644
--- a/core/txpool/validation.go
+++ b/core/txpool/validation.go
@@ -97,9 +97,19 @@ func ValidateTransaction(tx *types.Transaction, head *types.Header, signer types
 	}
 	// Transactions can't be negative. This may never happen using RLP decoded
 	// transactions but may occur for transactions created using the RPC.
-	if tx.Value().Sign() < 0 {
+	val := tx.Value()
+	if val.Sign() < 0 {
 		return ErrNegativeValue
 	}
+	if val.BitLen() > 256 {
+		return types.ErrUint256Overflow
+	}
+	// For legacy transactions, ensure gasPrice does not exceed 256 bits
+	if tx.Type() == types.LegacyTxType {
+		if tx.GasPrice().BitLen() > 256 {
+			return types.ErrUint256Overflow
+		}
+	}
 	// Ensure the transaction doesn't exceed the current block limit gas
 	if head.GasLimit < tx.Gas() {
 		return ErrGasLimit
diff --git a/core/txpool/validation_test.go b/core/txpool/validation_test.go
index 3945b548c1..b261c2d95d 100644
--- a/core/txpool/validation_test.go
+++ b/core/txpool/validation_test.go
@@ -96,6 +96,44 @@ func TestValidateTransactionEIP2681(t *testing.T) {
 	}
 }
 
+func TestValidateTransactionValueOverflow(t *testing.T) {
+	key, err := crypto.GenerateKey()
+	if err != nil {
+		t.Fatal(err)
+	}
+	head := &types.Header{
+		Number:     big.NewInt(1),
+		GasLimit:   5000000,
+		Time:       1,
+		Difficulty: big.NewInt(1),
+	}
+	signer := types.LatestSigner(params.TestChainConfig)
+	opts := &ValidationOptions{
+		Config:       params.TestChainConfig,
+		Accept:       0xFF,
+		MaxSize:      32 * 1024,
+		MaxBlobCount: 6,
+		MinTip:       big.NewInt(0),
+	}
+	to := common.HexToAddress("0x0000000000000000000000000000000000000001")
+	overflowValue := new(big.Int).Lsh(big.NewInt(1), 256)
+	tx := types.NewTx(&types.LegacyTx{
+		Nonce:    0,
+		To:       &to,
+		Value:    overflowValue,
+		Gas:      21000,
+		GasPrice: big.NewInt(1),
+	})
+	tx, err = types.SignTx(tx, types.HomesteadSigner{}, key)
+	if err != nil {
+		t.Fatal(err)
+	}
+	err = ValidateTransaction(tx, head, signer, opts)
+	if !errors.Is(err, types.ErrUint256Overflow) {
+		t.Fatalf("expected %v, got %v", types.ErrUint256Overflow, err)
+	}
+}
+
 // createTestTransaction creates a basic transaction for testing
 func createTestTransaction(key *ecdsa.PrivateKey, nonce uint64) *types.Transaction {
 	to := common.HexToAddress("0x0000000000000000000000000000000000000001")
diff --git a/internal/ethapi/api_test.go b/internal/ethapi/api_test.go
index b010eeaa08..2ed2042667 100644
--- a/internal/ethapi/api_test.go
+++ b/internal/ethapi/api_test.go
@@ -3968,6 +3968,11 @@ type configTimeBackend struct {
 	time    uint64
 }
 
+type overflowRejectingBackend struct {
+	*backendMock
+	lastTx *types.Transaction
+}
+
 func (b configTimeBackend) ChainConfig() *params.ChainConfig {
 	return b.genesis.Config
 }
@@ -3998,6 +4003,14 @@ func (b *testBackend) RPCTxSyncMaxTimeout() time.Duration {
 func (b *backendMock) RPCTxSyncDefaultTimeout() time.Duration { return 2 * time.Second }
 func (b *backendMock) RPCTxSyncMaxTimeout() time.Duration     { return 5 * time.Minute }
 
+func (b *overflowRejectingBackend) SendTx(ctx context.Context, tx *types.Transaction) error {
+	b.lastTx = tx
+	if tx.Value().BitLen() > 256 {
+		return types.ErrUint256Overflow
+	}
+	return nil
+}
+
 func makeSignedRaw(t *testing.T, api *TransactionAPI, from, to common.Address, value *big.Int) (hexutil.Bytes, *types.Transaction) {
 	t.Helper()
 
@@ -4089,6 +4102,43 @@ func TestSendRawTransactionSync_Timeout(t *testing.T) {
 	}
 }
 
+func TestSendRawTransactionRejectsValueOverflow(t *testing.T) {
+	t.Parallel()
+
+	key, err := crypto.HexToECDSA("b71c71a67e1177ad4e901695e1b4b9ee17ae16c6668d313eac2f96dbcda3f291")
+	require.NoError(t, err)
+
+	backend := &overflowRejectingBackend{backendMock: newBackendMock()}
+	api := NewTransactionAPI(backend, nil)
+
+	to := common.Address{0x42}
+	overflowValue := new(big.Int).Lsh(big.NewInt(1), 256)
+	tx, err := types.SignNewTx(key, types.LatestSigner(backend.ChainConfig()), &types.LegacyTx{
+		Nonce:    0,
+		GasPrice: big.NewInt(2),
+		Gas:      21000,
+		To:       &to,
+		Value:    overflowValue,
+	})
+	require.NoError(t, err)
+
+	raw, err := tx.MarshalBinary()
+	require.NoError(t, err)
+
+	_, err = api.SendRawTransaction(context.Background(), raw)
+	require.ErrorIs(t, err, types.ErrUint256Overflow)
+	require.NotNil(t, backend.lastTx)
+	require.Equal(t, overflowValue, backend.lastTx.Value())
+}
+
+func TestTxValidationErrorUint256Overflow(t *testing.T) {
+	t.Parallel()
+
+	err := txValidationError(types.ErrUint256Overflow)
+	require.Equal(t, errCodeInvalidParams, err.ErrorCode())
+	require.ErrorContains(t, err, types.ErrUint256Overflow.Error())
+}
+
 func TestGetStorageValues(t *testing.T) {
 	t.Parallel()
 
diff --git a/internal/ethapi/errors.go b/internal/ethapi/errors.go
index cc79af6f3c..cd9be8bd47 100644
--- a/internal/ethapi/errors.go
+++ b/internal/ethapi/errors.go
@@ -24,6 +24,7 @@ import (
 	"github.com/ethereum/go-ethereum/common"
 	"github.com/ethereum/go-ethereum/common/hexutil"
 	"github.com/ethereum/go-ethereum/core"
+	"github.com/ethereum/go-ethereum/core/types"
 	"github.com/ethereum/go-ethereum/core/vm"
 )
 
@@ -131,6 +132,8 @@ func txValidationError(err error) *invalidTxError {
 		return &invalidTxError{Message: err.Error(), Code: errCodeInvalidParams}
 	case errors.Is(err, core.ErrTipVeryHigh):
 		return &invalidTxError{Message: err.Error(), Code: errCodeInvalidParams}
+	case errors.Is(err, types.ErrUint256Overflow):
+		return &invalidTxError{Message: err.Error(), Code: errCodeInvalidParams}
 	case errors.Is(err, core.ErrTipAboveFeeCap):
 		return &invalidTxError{Message: err.Error(), Code: errCodeInvalidParams}
 	case errors.Is(err, core.ErrFeeCapTooLow):